viernes, 23 de diciembre de 2016

Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain

  1. Juan A. Saéz-Nieto
+Author Affiliations
  1. Laboratorio de Referencia e Investigación en Taxonomía, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Crta. Majadahonda-Pozuelo km 2.200, Majadahonda, Madrid, 28220, Spain
  1. *Corresponding author. Servicio de Bacteriología Centro Nacional de Microbiología, Instituto de Salud Carlos III, Crta. Majadahonda-Pozuelo km 2,200, Majadahonda, 28220 Madrid, Spain. Tel: +34-91-82237341; Fax: +34-91-5097966; E-mail:
  • Received May 17, 2016.
  • Revision requested July 31, 2016.
  • Revision received August 25, 2016.
  • Accepted October 12, 2016.


Objectives: The aims of this study were to explore the clinical distribution, by species, of the genus Nocardia and to assess the antimicrobial susceptibilities of the 10 most prevalent species identified in Spain.
Methods: Over a 10 year period (2005–14), 1119 Nocardia strains were molecularly identified and subjected to the Etest. The distribution and resistance trends over the sub-periods 2005–09 and 2010–14 were also examined.
Results: Of the strains examined, 82.9% belonged to the following species: Nocardia cyriacigeorgica (25.3%), Nocardia nova (15.0%), Nocardia abscessus (12.7%), Nocardia farcinica (11.4%), Nocardia carnea (4.3%), Nocardia brasiliensis (3.5%), Nocardia otitidiscaviarum (3.1%), Nocardia flavorosea (2.6%), Nocardia rhamnosiphila (2.6%) and Nocardia transvalensis (2.4%). Their prevalence values were similar during 2005–09 and 2010–14, except for those of N. abscessusN. farcinica and N. transvalensis, which fell significantly in the second sub-period (P ≤ 0.05). The major location of isolation was the respiratory tract (∼86%). Half (13/27) of all strains from the CNS were N. farcinica. Significant differences in MIC results were recorded for some species between the two sub-periods. According to the CLSI’s breakpoints, low resistance rates (≤15%) were recorded for seven species with respect to cefotaxime, imipenem and tobramycin; five species showed similar rates with respect to trimethoprim/sulfamethoxazole. Linezolid and amikacin were the most frequently active agents.
Conclusion: The accurate identification of the infecting species and the determination of its susceptibility to antimicrobial agents, given the large number of strains with atypical patterns, are crucial if patients with nocardiosis are to be successfully treated.

No hay comentarios.:

Publicar un comentario

Nota: sólo los miembros de este blog pueden publicar comentarios.